Factor IX

Factor IX in plasma is a single chain protein (Mr 55,000) and contains the vitamin K-dependent amino acid γ-carboxyglutamic acid. Activation of factor IX by factor XIa removes a 35 amino acid activation peptide to give a two-chain structure consisting of a light chain disulfide-bonded to a heavy chain. Factor IXa is the enzyme of the tenase complex which activates factor X to Xa in the presence of cofactor factor VIIIa, phospholipid and Ca2+.

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Factor IX Antibody General References


  1. Frazier, K.J. Smith, W.F. Cheung, J. Ware, S.W. Lin, A.R. Thompson, H. Reisner, S.P. Bajaj, D.W. Stafford. Mapping of monoclonal antibodies to human factor IX. (1989). Blood. 74(3):971-977.
  2. A.E. Schmidt, S.P. Bajaj.  Structure–function relationships in factor IX and factor IXa. (2003).Trends Cardiovasc Med. 13(1):39-45.
  3. R.G. Di Scipio, K. Kurachi, E.W. Davie.  Activation of human factor IX (Christmas factor). (1978). J Clin Invest. 61(6):1528-1538.
  4. H. Brandstetter, M. Bauer, R. Huber, P. Lollar, W. Bode. X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. (1995). Proc. Natl. Acad. Sci. USA. 92(21):9796-9800.

Showing all 9 results

    Catalog # Specificity Isotype ELISA Blotting Data Sheet and Pricing Add To Cart
  • GMA-001 Gla domain (residues 1-40) of FIX/FIXa IgG2a Gla domain (residues 1-40) of FIX/FIXa Human factor IX View Add To Cart
  • GMA-101 FIX/FIXa IgG1 Human FIX/IXa Not recommended View Add To Cart
  • GMA-102 Heavy chain of FIX/FIXa IgG1 Human and Porcine FIX, Human IXa Heavy chain of Human FIXa View Add To Cart
  • GMA-121 Light chain of FIX/FIXa IgG1 Human FIX/IXa Light chain of Human FIXa View Add To Cart
  • GMA-124 Light chain of FIX/FIXa IgG1 Human, Rat, Porcine, and Bovine FIX, Human FIXa Light chain of Human FIXa View Add To Cart
  • GMA-134 Human FIX (148T) IgG2a Immobilized Human FIX (148T) FIX (148T) View Add To Cart
  • GMA-138 FIX/IXa IgG1 Human, Bovine, Porcine, and Rat FIX, Human FIXa Not recommended View Add To Cart
  • GMA-181 Light chain of FIX/FIXa IgG2a Human FIX/IXa Light chain of FIXa View Add To Cart
  • GMA-184 Light chain of FIXa IgG2a Human FIX/IXa Light chain of FIXa View Add To Cart