Factor VIII

Factor VIII is a heterodimer of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (Mr 80,000) derived from the carboxy terminus of the protein. In plasma, factor VIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa is the plasma cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+.

Factor VIII General References


  1. G.A. Vehar, B. Keyt, D. Eaton, H. Rodriguez, D.P. O’Brien, Rotblat, H. Oppermann, R. Keck, W.I. Wood, R.N. Harkins, E.G. Tuddenham, R.M. Lawn, D.J. Capon. Structure of human factor VIII. (1984). Nature. 312(5992):337–342.
  2. P.J. Fay, P. J. Haidaris, T.M. Smudzin. Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit. (1991). J Biol Chem. 266(14):8957-8962.
  3. P.J. Fay. Activation of factor VIII and mechanisms of cofactor action. (2004). Blood Rev. 18(1):1-15.

Showing all 30 results

    Catalog # Specificity Isotype ELISA Blotting Data Sheet and Pricing Add To Cart
  • GMA-012 A2 domain residues 497-510 and 584-593, a discontinuous epitope and Glu604-Arg740[8] IgG1 A2 domain of human factor VIII and human factor VIIIa A2 domain View Add To Cart
  • GMA-8001 A3 domain IgG1 Human FVIII Not Recommended View Add To Cart
  • GMA-8002 A1 domain IgG2a A1 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8003 C2 domain IgG2a C2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8004 A1 domain IgG2a A1 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8005 A1 domain IgG2b A1 domain of recombinant Human Factor VIII Not recommended View Add To Cart
  • GMA-8006 C2 domain IgG2a C2 domain of recombinant human factor VIII Human FVIII View Add To Cart
  • GMA-8008 C2 domain IgG2a C2 domain of recombinant human factor VIII Not Recommended View Add To Cart
  • GMA-8009 FVIII A2 domain (residues Glu604-Arg740)1 IgG2 A2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8010 Light chain IgG2a LC domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8011 C1 domain IgG2a C1 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8012 A1A3 domain IgG2a Human, porcine, murine FVIII Not recommended View Add To Cart
  • GMA-8013 C2 domain IgG2a Human FVIII Not recommended View Add To Cart
  • GMA-8014 C2 domain IgG2b C2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8015 A2 domain IgG2a A2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8016 A2 domain IgG2a Human FVIII Not recommended View Add To Cart
  • GMA-8017 A2 domain IgG2a A2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8018 Light chain IgG2a Human, porcine, and murine FVIII Not recommended View Add To Cart
  • GMA-8019 Light chain IgG2a Human FVIII Not recommended View Add To Cart
  • GMA-8020 Light chain IgG2a Human FVIII Not recommended View Add To Cart
  • GMA-8021 A2 domain IgG2a A2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8022 C2 domain IgG2a C2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8023 A2 domain IgG2a A2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8024 A2 domain IgG1 A2 domain of recombinant human factor VIII Not recommended View Add To Cart
  • GMA-8025 C2 domain IgG2a Human FVIII C2 domain View Add To Cart
  • GMA-8026 C2 domain IgG2a Human FVIII Not recommended View Add To Cart
  • GMA-8027 C2 domain IgG2a Human FVIII Not recommended View Add To Cart
  • GMA-8040 A2 domain IgG1 LC of recombinant human factor VIII Light Chain View Add To Cart
  • GMA-8041 Light Chain IgG1 LC of recombinant human factor VIII Light Chain View Add To Cart
  • GMA-8045 Light Chain IgG1 LC of recombinant human factor VIII Not recommended View Add To Cart