Murine Anti-Factor IX

Clone GMA-181

Background

Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Absent or defective FIX is the cause of the X-linked recessive bleeding disorder hemophilia B. GMA-181 binds to FIX and detects the light chain of FIXa in both ELISA and Western blot formats.

Description

  • Species Reactivity:
    Human
  • Source:
    Murine
  • Specificity:
    Light chain of FIX/FIXa
  • Immunogen:
    Human Factor IX
  • Isotype:
    IgG2a

Application

  • ELISA:
    Binds immobilized Human FIX/IXa.
  • Immunoblotting:
    Western blotting detects Human FIXa and FIXa light chain under reduced conditions.
  • Inhibition:
    Does not prolong plasma clot time in APTT clotting assay.

Data

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GMA-181

$240.00$600.00

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0.1 mg/$240.00 0.5 mg/$600.00
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