GMA-8029

Murine Anti- Factor VIII

Clone GMA-8029

Background

Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8029 (also known as 3D12) recognizes the C2 domain of FVIII and inhibits the binding of FVIII to phospholipid membranes.1 It is suitable for ELISA, as well as surface plasmon resonance experiments.2

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human
Source: Murine
Specificity: C2 Domain
Immunogen: B-domain deleted recombinant Human Factor VIII
Isotype: IgG2b

Application

ELISA: Binds immobilized human FVIII.
Immunoblotting: Not recommended.
Inhibition: inhibitory in aPTT clotting assay.1

Data:

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