Case Study 1

Reagent Antibodies for Evaluation of Drug Levels and Activity in Patient Sera

Antibodies for Detection and Neutralization of Biotherapeutics

There is a need for antibodies in pre-clinical and clinical studies for the detection of potential biotherapeutic antibodies (Th-Mab) and also for the blocking of the therapeutic to its specific ligand target (anti-idiotypic/neutralizing (anti-ID Nab)).

As there is a potential for adverse effects on the animal’s immune system from either the active drug-antigen and/or resulting circulating antibody during the immunization phase, specifically designed immunization protocols are used to abrogate potential adverse effects.

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