Factor VIII

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Factor VIII Antibody Summary

Factor VIII (FVIII) is a large plasma glycoprotein that is essential for effective blood clotting. Factor VIII is produced in the liver and endothelial cells throughout the body. It has a heterodimeric structure composed of a heavy chain of A1 and A2 domains and a light chain made up of A3, C1 and C2 domains.

In plasma, Factor VIII circulates in an inactive form bound to von Willebrand factor. Following activation through cleavage by factor Xa or thrombin, the activated form factor VIIIa becomes the cofactor for Factor IXa, enabling activation of factor X.

Deficiency or lack of Factor VIII results in the disorder hemophilia A, characterized by excessive bleeding after tissue damage or injury. Historically, treatment of hemophilia A involved prophylactic clotting factor replacement therapy which includes frequent intravenous injections of FVIII. In about a third of cases, this can lead to the body’s development of inhibitor antibodies, which render the treatment less effective over time. Better treatment options, including those using gene therapy, are in clinical trials.

Green Mountain Antibodies has over thirty antibodies to human Factor VIII and mouse Factor VIII. Our murine anti-human FVIII antibodies were generated against B-domain deleted recombinant human FVIII.

Tested applications of FVIII antibodies include enzyme linked immunosorbent assay (ELISA), western blot, biolayer interferometry (BLI), surface plasmon resonance (SPR), immunohistochemistry, flow cytometry (FC), fluorescence activated cell sorting (FACS), and immunopurification, as well as identified sandwich pairs and knowledge of inhibitory capability. In addition, antibodies can be labeled with biotin or fluorescent markers at your request.

Summary table of our Inhibitory Antibodies.

Summary table of our Western Blotting Antibodies.

All Products

All Products
Catalog #
Specificity
Antigen
Applications
GMA-012
A2 domain
Factor VIII
ELISA, western blot, biolayer interferometry, immunopurification
GMA-780
Factor VIII
ELISA, western blot
GMA-781
Factor VIII
ELISA, inhibitory
GMA-8001
A3 Domain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8002
A1 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8003
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance
GMA-8004
A1 domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance
GMA-8005
A1 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8006
C2 Domain
Factor VIII
ELISA, biolayer interferometry, flow cytometry, surface plasmon resonance, inhibitory
GMA-8008
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance, inhibitory
GMA-8009
FVIII A2 domain (residues Glu604-Arg740)1
Factor VIII
ELISA, biolayer interferometry, immunohistochemistry, FACS, inhibitory
GMA-8010
Light Chain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8011
C1 domain
Factor VIII
ELISA, surface plasmon resonance
GMA-8012
A1A3 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8013
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance, inhibitory
GMA-8014
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance, inhibitory
GMA-8015
A2 domain
Factor VIII
ELISA, inhibitory
GMA-8016
A2 domain
Factor VIII
ELISA, biolayer interferometry, immunopurification
GMA-8017
A2 domain
Factor VIII
ELISA
GMA-8018
Light Chain
Factor VIII
ELISA, inhibitory
GMA-8019
Light Chain
Factor VIII
ELISA, inhibitory
GMA-8020
Light Chain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8021
A2 domain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8022
C2 Domain
Factor VIII
ELISA, inhibitory
GMA-8023
A2 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8024
A2 domain
Factor VIII
ELISA
GMA-8025
C2 Domain
Factor VIII
ELISA, western blot
GMA-8026
C2 Domain
Factor VIII
ELISA, inhibitory
GMA-8027
C2 Domain
Factor VIII
ELISA
GMA-8028
A2 domain
Factor VIII
ELISA, western blot, inhibitory
GMA-8029
C2 Domain
Factor VIII
ELISA, surface plasmon resonance, inhibitory
GMA-8040
Light Chain
Factor VIII
ELISA, western blot
GMA-8041
Light Chain
Factor VIII
ELISA, western blot
GMA-8045
Light Chain
Factor VIII
ELISA
Human Coagulation Factors and Plasma Antigens

Human Coagulation Factors and Plasma Antigens

All Products
Catalog #
Specificity
Antigen
Applications
GMA-001
Gla domain (residues 1-40) of FIX/FIXa
Factor IX
calcium dependence, ELISA, western blot, inhibitory
GMA-004
Factor XIII
ELISA
GMA-012
A2 domain
Factor VIII
ELISA, western blot, biolayer interferometry, immunopurification
GMA-013
Kringles 1-3 segment of plasminogen
Plasminogen / Angiostatin
ELISA, western blot
GMA-014
α-2-macroglobulin
Alpha-2-Macroglobulin
ELISA, western blot
GMA-016
Kringles 1-4 segment of plasminogen
Plasminogen / Angiostatin
ELISA, western blot
GMA-020
a-thrombin B-chain (residues 321- 579 of prothrombin)
Thrombin
ELISA, western blot
GMA-022
vWF
ELISA, western blot
GMA-030
Kringle 5-B chain
Plasminogen / Angiostatin
ELISA
GMA-033
B subunit
Factor XIII
ELISA, western blot
GMA-034
Human fibrinogen
Fibrinogen
ELISA, western blot
GMA-035
Human fibrinogen
Fibrinogen
ELISA, western blot
GMA-036
C4b Binding Protein
ELISA, immunopurification
GMA-039
Kringle 5-B chain
Plasminogen / Angiostatin
ELISA, western blot, biolayer interferometry, immunopurification
GMA-043
Tissue Plasminogen Activator
ELISA, western blot
GMA-044
FV, FVa heavy chain
Factor V
ELISA, western blot
GMA-046
Protein S
ELISA
GMA-047
Protein S
ELISA, western blot
GMA-053
Protein C
Protein C
ELISA, western blot
GMA-054
activation region of Protein C
Protein C
ELISA, western blot, calcium dependence
GMA-067
Protein C heavy chain
Protein C
ELISA, western blot
GMA-070
Factor XI/XIa
Factor XI
ELISA, western blot, immunopurification
GMA-072
Factor XI/XIa
Factor XI
ELISA, western blot
GMA-086
plasminogen
Plasminogen / Angiostatin
ELISA, western blot
GMA-091
Prothrombin
ELISA, western blot
GMA-093
Protein C heavy chain
Protein C
ELISA, western blot
GMA-095
Prethrombin-1 (residues 272-579 of prothrombin)
Prothrombin
ELISA, western blot
GMA-097
prethrombin 1, prethrombin 2, prothrombin
Prothrombin
western blot
GMA-099
transferrin
Transferrin
ELISA, western blot
GMA-101
FIX/FIXa
Factor IX
immunohistochemistry, ELISA
GMA-102
Heavy chain of FIX/FIXa
Factor IX
ELISA, western blot, inhibitory, biolayer interferometry
GMA-121
Light chain of FIX/FIXa
Factor IX
ELISA, western blot
GMA-124
Light chain of FIX/FIXa
Factor IX
ELISA, western blot, biolayer interferometry
GMA-134 (previously known as GMA-133)
Human FIX (148T)
Factor IX
detects FIX with Thr 148 in ELISA, western blot, biolayer interferometry
GMA-138
FIX/IXa
Factor IX
ELISA, biolayer interferometry
GMA-142
Factor XII Heavy Chain
Factor XII
ELISA, western blot
GMA-140
Factor XII
Factor XII
ELISA, western blot
GMA-145
Factor XII
Factor XII
western blot
GMA-144
Factor XII/XIIa
Factor XII
ELISA, western blot
GMA-146
Factor XII/XIIa
Factor XII
ELISA, western blot
GMA-147
Factor XII/XIIa
Factor XII
western blot
GMA-143
Factor XII/XIIa
Factor XII
ELISA, western blot
GMA-148
Factor XII/XIIa
Factor XII
western blot
GMA-141
Factor XII/XIIa
Factor XII
ELISA, western blot
GMA-184
Light chain of FIXa
Factor IX
ELISA, western blot, biolayer interferometry
GMA-213
Factor VII/VIIa
Factor VII
ELISA, western blot, immunohistochemistry
GMA-219
Factor VII/VIIa
Factor VII
ELISA, western blot
GMA-320
Extracellular domain of tissue factor.
Tissue Factor
ELISA, western blot
GMA-340
Shedding cleavage site of GPIba
GPIba
ELISA, western blot
GMA-350
Disintegrin domain of ADAMTS13
ADAMTS13
ELISA, western blot, immunohistochemistry, immunopurification
GMA-454
Proteinase-activated receptor 1
ELISA
GMA-505
Factor X/Xa
Factor X
ELISA, western blot
GMA-508
Factor X heavy chain
Factor X
ELISA, western blot
GMA-509
Factor X light chain
Factor X
ELISA, western blot
GMA-520
Factor X light chain
Factor X
ELISA, western blot
GMA-529
Factor X/Xa
Factor X
ELISA, western blot, inhibitory
GMA-550
Factor X/Xa
Factor X
ELISA, western blot
GMA-560
Factor X heavy chain
Factor X
calcium dependence, ELISA, western blot
GMA-800
Antithrombin
ELISA, inhibitory
GMA-900
Vitronectin
ELISA, western blot, immunopurification
GMA-5001
FV, FVa light chain
Factor V
ELISA, inhibitory, biolayer interferometry
GMA-5007
FV, FVa activation fragment
Factor V
ELISA, western blot, immunopurification
GMA-5017
FV/Va heavy chain, residues 307-5061
Factor V
ELISA, western blot
GMA-8001
A3 Domain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8002
A1 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8003
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance
GMA-8004
A1 domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance
GMA-8005
A1 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8006
C2 Domain
Factor VIII
ELISA, biolayer interferometry, flow cytometry, surface plasmon resonance, inhibitory
GMA-8008
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance, inhibitory
GMA-8009
FVIII A2 domain (residues Glu604-Arg740)1
Factor VIII
ELISA, biolayer interferometry, immunohistochemistry, FACS, inhibitory
GMA-8010
Light Chain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8011
C1 domain
Factor VIII
ELISA, surface plasmon resonance
GMA-8012
A1A3 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8013
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance, inhibitory
GMA-8014
C2 Domain
Factor VIII
ELISA, biolayer interferometry, surface plasmon resonance, inhibitory
GMA-8015
A2 domain
Factor VIII
ELISA, inhibitory
GMA-8016
A2 domain
Factor VIII
ELISA, biolayer interferometry, immunopurification
GMA-8017
A2 domain
Factor VIII
ELISA
GMA-8018
Light Chain
Factor VIII
ELISA, inhibitory
GMA-8019
Light Chain
Factor VIII
ELISA, inhibitory
GMA-8020
Light Chain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8021
A2 domain
Factor VIII
ELISA, biolayer interferometry, inhibitory
GMA-8022
C2 Domain
Factor VIII
ELISA, inhibitory
GMA-8023
A2 domain
Factor VIII
ELISA, biolayer interferometry
GMA-8024
A2 domain
Factor VIII
ELISA
GMA-8025
C2 Domain
Factor VIII
ELISA, western blot
GMA-8026
C2 Domain
Factor VIII
ELISA, inhibitory
GMA-8027
C2 Domain
Factor VIII
ELISA
GMA-8028
A2 domain
Factor VIII
ELISA, western blot, inhibitory
GMA-8029
C2 Domain
Factor VIII
ELISA, surface plasmon resonance, inhibitory
GMA-8040
Light Chain
Factor VIII
ELISA, western blot
GMA-8041
Light Chain
Factor VIII
ELISA, western blot
GMA-8045
Light Chain
Factor VIII
ELISA
Bovine Immune Markers

Bovine Immune Markers

All Products
Catalog #
Specificity
Antigen
Applications
GMA-3011 (IL-A11)
Bovine CD41
CD4
-
GMA-3021 (IL-A21)
Bovine MHC Class II1
MHC Class II
-
GMA-3024 (IL-A24)
Bovine CD172a (myeloid cells)1
CD172a
-
GMA-3030 (IL-A30)
Bovine IgM1
IgM
ELISA
GMA-3060 (IL-A60)
Bovine IgG11
IgG1
ELISA
GMA-3071 (IL-A71)
Bovine IgA1
IgA
ELISA
GMA-3074
Bovine IgG2
IgG2
ELISA
GMA-3088 (IL-A88)
Bovine MHC Class I1
MHC Class I
-
GMA-3105 (IL-A105)
Bovine CD8α and CD8βα1
CD8
-
GMA-3111 (IL-A111)
Bovine CD251
CD25
-
GMA-3130 (IL-A130)
Bovine CD11b1
CD11b
-
Mouse Coagulation Factors and Plasma Antigens

Mouse Coagulation Factors and Plasma Antigens

All Products
Catalog #
Specificity
Antigen
Applications
GMA-737
Factor XIII
ELISA, western blot
GMA-739
Factor XIII
ELISA, western blot
GMA-740
Factor XIII
ELISA, western blot
GMA-741
Factor XIII
ELISA
GMA-751
Factor V
ELISA, inhibitory
GMA-752
Factor V
ELISA, inhibitory
GMA-753
Factor V
ELISA, western blot
GMA-754
Factor V
ELISA
GMA-755
Factor V
ELISA, inhibitory
GMA-756
Factor V
ELISA, inhibitory
GMA-762
Factor X light chain
Factor X
ELISA, western blot, inhibitory
GMA-763
Factor X light chain
Factor X
ELISA, western blot, inhibitory
GMA-767
Factor X/Xa
Factor X
ELISA
GMA-769
Factor X/Xa
Factor X
ELISA, western blot
GMA-780
Factor VIII
ELISA, western blot
GMA-781
Factor VIII
ELISA, inhibitory
GMA-792
Prothrombin
ELISA, western blot
GMA-793
Prothrombin
ELISA
Control Antigens

Control Antigens

All Products
Catalog #
Specificity
Antigen
Applications
GMA-610
Rabbit IgG
ELISA
GMA-630
BSA and peptide-BSA conjugates.
Bovine Serum Albumin Antibody
ELISA
GMA-640
Ovalbumin
ELISA
GMA-660
Bovine IgG
ELISA
GMA-721
Keyhole Limpet Hemocyanin (KLH)
ELISA

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