Platelet membrane glycoprotein Ib (GPIba) is comprised of an a and b subunit linked by disulfide bonds. GPIba (also known as CD42b) is a 135 kDa membrane protein subunit that binds a variety of adhesive and procoagulant ligands, including von Willebrand factor. Cleavage of GPIba by the “sheddase” ADAM17 releases the ectodomain glycocalicin into plasma. ADAM17 cleaves GPIba at Gly464-Val465.
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- GMA-340 Shedding cleavage site of GPIba ELISA, western blot View Product Specifications Pricing