Thrombin, the protease cleavage product of prothrombin by prothrombinase, is a two-chain protein (Mr 37,000) consisting of an amino-terminal A chain (Mr 6,000) disulfide-bonded to a carboxyl-terminal B chain (Mr 31,000). Thrombin has numerous physiological roles including cleavage of Aα and Bβ peptides of fibrinogen to form fibrin, activation of factor V, factor VIII, and protein C, and platelet activation via cleavage of PAR-1 and PAR-4.
- Species Reactivity:Human
- Specificity:a-thrombin B-chain (residues 321- 579 of prothrombin)
- Immunogen:Human Thrombin
- ELISA:Binds immobilized human thrombin, prothrombin, prethrombin 1 and prethrombin 2.
- Immunoblotting:Western blot detects thrombin, prothrombin, prethrombin 1 and prethrombin 2
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