ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 repeat, member 13) is also known as von Willebrand factor-cleaving protease (VWFCP). It is a 195 kDa plasma glycoprotein that cleaves the Tyr1605-Met1606 bond in the A2 domain of von Willebrand factor. IgG autoantibodies against ADAMTS13 are a primary cause of the potentially fatal syndrome thrombotic thrombocytopenic purpura (TTP). GMA-350 binds the disintegrin domain of ADAMTS13 and is suitable for affinity purification, immunostaining in cells, Western blot, and ELISA.
- Species Reactivity:Human
- Specificity:Disintegrin domain of ADAMTS13
- Immunogen:Disintegrin domain of ADAMTS13
- ELISA:Binds the disintegrin domain of ADAMTS13.
- Immunoblotting:Binds the disintegrin domain of ADAMTS13.
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