GMA-5017

Murine Anti- Factor V

Clone GMA-5017

Background

Factor V (FV) circulates in blood as a single chain protein (Mr 330,000). Following proteolytic activation by thrombin, activated factor V (FVa) serves as the cofactor for factor Xa in the prothrombinase complex that cleaves prothrombin to thrombin in the presence of phospholipid and Ca2+. Factor Va is composed of a heavy chain (Mr 94,000) non-covalently associated to a light chain (Mr 74,000). GMA-5017 recognizes the heavy chain of FVa and is suitable for ELISA and Western blot applications.

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human
Specificity: FV/Va heavy chain, residues 307-5061
Immunogen: Human Factor V
Isotype: IgG2a

Application

ELISA: Binds immobilized human FV and FVa.
Immunoblotting: Western blot detects FV/FVa heavy chain.

Data:

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  • 0.1 mg/$265.00
  • 0.5 mg/$660.00
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Antibody References:

  1. R.M. Camire, M. Kalafatis, P.B. Tracy. (1998). Biochemistry. 37(34):11896-906.
  2. R.M. Camire, M. Kalafatis, P. Simioni, A. Girolami, P.B. Tracy. (1998). Blood. 91(8):2818-29.