Murine Anti-Factor V
Factor V (FV) circulates in blood as a single chain protein (Mr 330,000). Following proteolytic activation by thrombin, activated factor V (FVa) serves as the cofactor for factor Xa in the prothrombinase complex that cleaves prothrombin to thrombin in the presence of phospholipid and Ca2+. Factor Va is composed of a heavy chain (Mr 94,000) non-covalently associated to a light chain (Mr 74,000). Absent or defective FIX is the cause of the bleeding disorder hemophilia B. GMA-5017 recognizes the heavy chain of FVa and is suitable for ELISA and Western blot applications.
- Species Reactivity:Human
- Specificity:FV/Va heavy chain, residues 307-5061
- Immunogen:Human Factor V
- ELISA:Binds immobilized human FV and FVa.
- Immunoblotting:Western blot detects FV/FVa heavy chain.
$265.00 – $660.00