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GMA-8006

You are here: Home / Human Plasma Antigens / GMA-8006
Return to Factor VIII Summary Page

Murine Anti-Factor VIII

Clone GMA-8006

Background

Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8006 (also known as 2-77 or (2) 77-1C)1 recognizes the C2 domain of FVIII and strongly inhibits FVIII activation. It is suitable for flow cytometry2, ELISA, bio-layer interferometry pairing, and surface plasmon resonance experiments.3

More Information

Product Datasheet as PDF

Description

  • Species Reactivity:
    Human
  • Source:
    Murine
  • Specificity:
    C2 domain
  • Immunogen:
    B-domain deleted recombinant Human Factor VIII
  • Isotype:
    IgG2a

Application

  • ELISA:
    Binds the C2 domain of recombinant human factor VIII in solid-phase ELISA.
  • Immunoblotting:
    Not recommended
  • Inhibition:
    Strongly inhibitory in aPTT clotting assay.1

Data

Text_2

Antibody References

  1. S.L. Meeks et al. (2007). Blood. 110(13):4234-4242.
  2. G.S. Pandey et al. (2013). Nat Med. 19(10):1318–1324.
  3. P.T. Nguyen et al. (2014). Blood. 123(17):2732-2739.

$265.00 – $660.00

Buy: GMA-8006
0.5 mg/$660.00 0.1 mg/$265.00
For larger amounts, please call.
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