• Skip to primary navigation
  • Skip to main content

802-865-6230

info@greenmoab.com

Customer Login

Green Mountain Antibodies

Green Mountain Antibodies

Antibodies in the Service of Science and Life

  • Home
  • Antibody Services
    • Antibody Development
      • Mouse Monoclonal Antibodies: Hybridoma Development
      • Anti-Idiotypic Antibodies
      • Polyclonal Antibody Production
      • Repetitive Immunizations Multiple Sites (RIMMS)
    • Production & Purification
      • Large Scale Antibody Production and Purification
    • Antibody Characterization
      • ELISA Assay Development
      • Antibody Characterization
      • Octet Analysis
      • Antibody Sequencing
  • Buy Antibodies
    • Factor VIII
    • Factor IX
    • Bovine Serum Albumin (BSA)
    • Antithrombin
    • See all products
  • The Science
    • Antibody Development Process
    • Variables for Success
    • FAQs
    • Accomplishments & Case Studies
    • Warranty Policy
  • About
    • About Us
    • Meet the Team
    • Mission, Vision, Values
    • Testimonials
    • Careers
  • Contact Us
  • View Cart

GMA-8008

You are here: Home / Human Plasma Antigens / GMA-8008
Return to Factor VIII Summary Page

Murine Anti-Factor VIII

Clone GMA-8008

Background

Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8008 (also known as 1B5 or 1B5.1B)1 recognizes the C2 domain of FVIII, inhibits FVIII activation by thrombin or factor Xa, but does not inhibit the binding of FVIII to phospholipid membranes1. It is suitable for ELISA and bio-layer interferometry pairing experiments, as well as surface plasmon resonance.2,3

More Information

Product Datasheet as PDF

Description

  • Species Reactivity:
    Human
  • Source:
    Murine
  • Specificity:
    C2 domain
  • Immunogen:
    B-domain deleted recombinant Human Factor VIII
  • Isotype:
    IgG2a

Application

  • ELISA:
    Binds the C2 domain of recombinant human factor VIII in solid-phase ELISA.
  • Immunoblotting:
    Not recommended.
  • Inhibition:
    Inhibitory in aPTT clotting assay.1

Data

Text_2

Antibody References

  1. S.L. Meeks et al. (2007). Blood. 110(13):4234-4242.
  2. P.T. Nguyen et al. (2014). Blood. 123(17):2732-2739.
  3. N.C. Leksa et al. (2017). J Thromb Haemost. 15(6):1167–1179.
  4. S. Krishnamoorthy et al. (2016). Cell Immunol. 301:30-39.
  5. J.C. Lin et al. (2015). PLOS ONE. 10(1):1-19.
  6. G.S. Pandey et al. (2013). Nat Med. 19(10):1318–1324.
  7. L. L. Swystun et al. (2019). J Thromb Haemost.. 17(4): 681–694.

$265.00 – $660.00

Buy: GMA-8008
0.5 mg/$660.00 0.1 mg/$265.00
For larger amounts, please call.
Amount:
Quantity:
Shop More

Antibodies in the Service of Science and Life

Products & Services

Purified Monoclonal Antibody Products

Antibody Development

Monoclonal Antibody Production & Purification

Antibody Characterization

The Science

Antibody Development Process

Variables for Success

FAQ’s

Accomplishments & Case Studies

Warranty Policy

About Us

About Us

Meet the Team

Mission, Vision, Values

Testimonials

Careers

Get in Touch

Green Mountain Antibodies

Burlington, VT 05402

802-865-6230
info@greenmoab.com
  • Facebook
  • LinkedIn

Copyright 2021 - Green Mountain Antibodies