Murine Anti-Factor VIII
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8010 (also known as 1E12 or 1E12.1B) recognizes the light chain of FVIII. The antibody inhibits FVIII activation and is suitable for ELISA and bio-layer interferometry pairing experiments.
- Species Reactivity:Human, pig
- Specificity:Light chain
- Immunogen:B-domain deleted recombinant Human Factor VIII
- ELISA:Binds the LC domain of recombinant human factor VIII in solid-phase ELISA.
- Immunoblotting:Not recommended.
- Inhibition:Inhibitory in aPTT clotting assay.
$265.00 – $660.00