GMA-8020

Clone GMA-8020

Background

Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8020 (also known as 6A8 or 6A8.1B) recognizes the A1-A3 domains of FVIII and partially inhibits FVIII activation. It is suitable for ELISA and bio-layer interferometry pairing experiments.

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human
Source: Murine
Specificity: Light Chain
Immunogen: B-domain deleted recombinant human FVIII
Isotype: IgG2a

Application

ELISA: Binds immobilized human FVIII.
Immunoblotting: Not recommended.
Inhibition: Inhibitory in aPTT clotting assay.

Data:

Purchase GMA-8020

  • 0.5 mg/$660.00
  • 0.1 mg/$265.00
For Larger Amounts Please Call:
(802) 865-6230
Quantity:
Continue Shopping