GMA-8025
Murine Anti- Factor VIII
Clone GMA-8025
Background
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8025 (also known as 2D12) recognizes the C2 domain of FVIII and is suitable for ELISA and Western blot applications.
More Information:
Product Datasheet, pdfDescription
Source: Murine
Specificity: C2 Domain
Immunogen: B-domain deleted recombinant Human Factor VIII
Isotype: IgG2a
Application
ELISA: Binds immobilized human FVIII.
Immunoblotting: Western blot detects C2 domain of human FVIII under reduced conditions.
Data:
