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GMA-8009

You are here: Home / Human Plasma Antigens / GMA-8009
Return to Factor VIII Summary Page

Murine Anti-Factor VIII

Clone GMA-8009

Background

Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8009 (also known as 1D4 or 1D4.1B)1 recognizes the A2 domain of FVIII and inhibits FVIII activation by thrombin or factor Xa. It is suitable for immunohistochemistry and FACS2, ELISA and bio-layer interferometry pairing experiments.

More Information

Product Datasheet as PDF

Description

  • Species Reactivity:
    Human
  • Source:
    Murine
  • Specificity:
    FVIII A2 domain (residues Glu604-Arg740)1
  • Immunogen:
    B-domain deleted recombinant Human Factor VIII
  • Isotype:
    IgG2a

Application

  • ELISA:
    Binds the A2 domain of recombinant human factor VIII in solid-phase ELISA.
  • Immunoblotting:
    Not recommended.
  • Inhibition:
    Strongly inhibitory in aPTT clotting assay.1

Data

Text_2

Antibody References

  1. R.C. Markovitz et al. (2013). Blood. 121(14):2785-2795.
  2. A. van der Flier et al. (2015). PLOS One. 10(4):e0124930.
  3. R.J. Summers et al. (2011). Blood. 117(11):3190-3198.

$265.00 – $660.00

Buy: GMA-8009
0.5 mg/$660.00 0.1 mg/$265.00
For larger amounts, please call.
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