GMA-020

Clone GMA-020

Background

Thrombin, the protease cleavage product of prothrombin by prothrombinase, is a two-chain protein (Mr 37,000) consisting of an amino-terminal A chain (Mr 6,000) disulfide-bonded to a carboxyl-terminal B chain (Mr 31,000). Thrombin has numerous physiological roles including cleavage of Aα and Bβ peptides of fibrinogen to form fibrin, activation of factor V, factor VIII, and protein C, and platelet activation via cleavage of PAR-1 and PAR-4. Antibody binds immobilized human thrombin, prothrombin, prethrombin 1 and prethrombin 2 in ELISA.