GMA-121
Murine Anti- Factor IX
Clone GMA-121
Background
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Defect or deficiencies in FIX lead to the X-linked recessive bleeding disorder hemophilia B. GMA-121 binds to FIX and detects the light chain of FIXa in both ELISA and Western blot format.
More Information:
Product Datasheet, pdfDescription
Species Reactivity: Human
Source: Murine
Specificity: Light chain of FIX/FIXa
Immunogen: Human Factor IX
Isotype: IgG1
Application
ELISA: Binds immobilized Human FIX/IXa.
Immunoblotting: Western blotting detects human FIX and Human FIXa light chain under reduced conditions.
Inhibition: Does not prolong plasma clot time in APTT clotting assay.
Data:
