GMA-5007

Murine Anti- Factor V

Clone GMA-5007

Background

Factor V (FV) circulates in blood as a single chain protein (Mr 330,000). Following proteolytic activation by thrombin, activated factor V (FVa) serves as the cofactor for factor Xa in the prothrombinase complex that cleaves prothrombin to thrombin in the presence of phospholipid and Ca2+. Factor Va is composed of a heavy chain (Mr 94,000) non-covalently associated to a light chain (Mr 74,000). GMA-5007 recognizes the activation fragment of FVa,1 binds FV and FVa under reduced and non-reduced conditions,and can be used for purification of the activation fragment.1

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human
Source: Murine
Specificity: FV, FVa activation fragment
Immunogen: Human Factor V
Isotype: IgG1

Application

ELISA: Binds immobilized human FV and FVa.
Immunoblotting: Binds Factor V and factor Va under reduced and non-reduced conditions.

Data:

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  • 0.5 mg/$660.00
  • 0.1 mg/$265.00
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Antibody References:

  1. W. B. Foster, M. M. Tucker, J. A. Katzmann, R. S. Miller, M. E. Nesheim, K. G. Mann. (1983). Blood. 61(6):1060-7.