GMA-054

Murine Anti- Protein C

Clone GMA-054

Background

Thrombin, in the presence of thrombomodulin, cleaves protein C giving the active protease activated protein C (APC). APC plays a regulatory role in coagulation by functioning as an anticoagulant by proteolytic inactivation of Factors V (Va) and VIII (VIIIa). Protein C (Mr 62,000) consists of a heavy chain (Mr 41,000) disulfide bonded to a Gla-containing light chain (Mr 21,000) which contains two EGF domains. GMA-054 is calcium dependent, and recognizes the activation region of Protein C. It can be used in western blot and ELISA applications. GMA-054 does not recognize activated Protein C and inhibits activation of Protein C by thrombin-thrombomodulin.

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Baboon, Canine, Human, Pig
Source: Murine
Specificity: activation region of Protein C
Immunogen: Human Protein C
Isotype: IgG1

Application

ELISA: Binds immobilized human protein C only in the presence of calcium.
Immunoblotting: Binds protein C under reduced and non-reduced conditions.
Inhibition: Inhibits activation of Protein C by thrombin-thrombomodulin.

Data:

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Antibody References:

  1. Esmon, C. (1993). U.S. Patent No. 5,202,253.