GMA-134 (previously known as GMA-133)
Murine Anti- Factor IX
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. A polymorphism is found in plasma-derived FIX within the activation peptide. The amino acid at position 148 exists as either a threonine or an alanine. GMA-134 (previously known as GMA-133) binds to FIX with threonine at the 148 position and detects FIX (148T) in ELISA and Western blot formats with no detectable binding to FIX (148A). In addition, bound GMA-134 captures FIX (148T) by bio-layer interferometry.
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