Murine Anti- GPIba

Clone GMA-340


Platelet membrane glycoprotein Ib (GPIba) is comprised of an alpha and beta subunit linked by disulfide bonds. GPIba (also known as CD42b) is a 135 kDa membrane protein subunit that binds a variety of adhesive and procoagulant ligands, including von Willebrand factor. Cleavage of GPIba by the “sheddase” ADAM17 releases the ectodomain glycocalicin into plasma. ADAM17 cleaves GPIba at Gly464-Val465. Liang et al. have shown that the murine monoclonal antibody designated 5G6 (GMA-340) binds the ADAM17 cleavage site and blocks glycocalicin release.

More Information:

Product Datasheet, pdf


Species Reactivity: Human
Source: Murine
Specificity: Shedding cleavage site of GPIba
Immunogen: Human GPIba peptide (Ac-ELDQPPKLRG VLQGHLESSRNDPFC- amide) conjugated to ovalbumin.
Isotype: IgG1


ELISA: Binds immobilized human platelet GPIba and synthetic peptide
Immunoblotting: Binds under reduced and non-reduced conditions


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  • 0.5 mg/$660.00
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