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GMA-5001

Murine Anti- Factor V

Clone GMA-5001

Background

Factor V (FV) circulates in blood as a single chain protein (Mr 330,000). Following proteolytic activation by thrombin, activated factor V (FVa) serves as the cofactor for factor Xa in the prothrombinase complex that cleaves prothrombin to thrombin in the presence of phospholipid and Ca2+. Factor Va is composed of a heavy chain (Mr 94,000) non-covalently associated to a light chain (Mr 74,000). GMA-5001 (previously known as GMA-081) recognizes the light chain of FVa and is inhibitory in aPTT-based clotting assays.

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human
Source: Murine
Specificity: FV, FVa light chain
Immunogen: Human Factor V
Isotype: IgG1

Application

ELISA: Binds immobilized human FV and FVa.
Immunoblotting: Not recommended.
Inhibition: Inhibitory in aPTT clotting assay.

Data:

Purchase GMA-5001

  • 0.5 mg/$660.00
  • 0.1 mg/$265.00
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Antibody References:

  1. W. B. Foster, M. M. Tucker, J. A. Katzmann, R. S. Miller, M. E. Nesheim, K. G. Mann. (1983). Blood. 61(6):1060-7.
  2. J. A. Katzmann, M. E. Nesheim, L. S. Hibbard, K. G. Mann. (1981). PNAS. 78(1):162-6.