GMA-8001
Murine Anti- Factor VIII
Clone GMA-8001
Background
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8001 (also known as 2-113)1 recognizes the A3 domain of FVIII, is suitable for ELISA and bio-layer interferometry pairing applications.
More Information:
Product Datasheet, pdfDescription
Species Reactivity: Human
Source: Murine
Specificity: A3 Domain
Immunogen: B-domain deleted recombinant Human Factor VIII
Isotype: IgG1
Application
ELISA: Binds the A3 domain of recombinant human factor VIII in solid-phase ELISA.
Immunoblotting: Not recommended.
Inhibition: Moderately inhibitory in aPTT clotting assay.
Data:
