Murine Anti- Factor VIII
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8040 is suitable for ELISA and Western blot applications.
More Information:Product Datasheet, pdf
Species Reactivity: Human
Specificity: Light Chain
Immunogen: Recombinant human FVIII light chain (residue numbers1689-2332)
ELISA: Binds immobilized human FVIII.
Immunoblotting: Detects FVIII LC
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