NEAH-3111
IL-A111
Background:
Mouse anti Bovine CD25 antibody, clone IL-A111, recognizes the bovine CD25 cell surface antigen, a ~55 kDa tranamembrane receptor glycoprotein also known as IL-2 receptor alpha chain (IL-2Rα) expressed on activated T and B cells and NK cells. CD25 binds to IL-2, inducing proliferation of the activated cells and can also mediate apoptosis. Bovine CD25 is expressed by activated T cells. This antibody is reported to block the IL-2 driven proliferation of Con A-induced blast cells/bovine lymphocytes.
This product is currently out of stock. Expected availability: 4th Quarter 2024
Description
Application
Purchase NEAH-3111
Antibody References:
“Naessens, J. et al. 1992. Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene. Immunology. 76 (2): 305-9. Howard, C.J. & Naessens, J. 1993. Summary of workshop findings for cattle (tables 1 and 2). Vet Immunol Immunopathol. 39 (1-3): 25-47. Howard, C.J. et al. 1997. Identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate T cells. J Immunol. 159 (11): 5372-82.”
Questions about this product?
Contact Bill Golde, Chief Science Officer at New England Animal Health: bill.golde@neah.org