Murine Anti-Factor IX

Clone GMA-138

Background

Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Defect or deficiencies in FIX lead to the X-linked recessive bleeding disorder hemophilia B. GMA-138 binds to FIX and FIXa in ELISA assays, and bound GMA-138 detects human FIX by bio-layer interferometry.

More Information

Description

  • Species Reactivity:
    Human, Bovine, Porcine, and Rat
  • Source:
    Murine
  • Specificity:
    FIX/IXa
  • Immunogen:
    Human Factor IX
  • Isotype:
    IgG1

Application

  • ELISA:
    Binds immobilized Human, Bovine, Porcine, and Rat FIX and Human FIXa
  • Immunoblotting:
    Not recommended for Western blotting.
  • Octet KD (M):
    KD= 30 nM (kdis=4.4x10-3 sec-1) by bio-layer interferometry
  • Inhibition:
    Does not prolong plasma clot time in APTT clotting assay.

Data

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GMA-138

$240.00$600.00

Buy: GMA-138
0.5 mg/$600.00 0.1 mg/$240.00
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