Protein C

Protein C Antibody Summary

Protein C is a vitamin K–dependent plasma glycoprotein that plays a critical role in the regulation of blood coagulation. Synthesized in the liver, Protein C circulates in plasma as an inactive zymogen and is activated to activated Protein C (APC) through proteolytic cleavage by the thrombin–thrombomodulin complex on endothelial cell surfaces.

Once activated, APC serves as a potent anticoagulant by inactivating Factors Va and VIIIa, thereby downregulating thrombin generation and preventing excessive clot formation. In addition to its anticoagulant activity, APC exhibits cytoprotective and anti-inflammatory effects, contributing to vascular integrity and endothelial health.

Contact us if you would like to obtain small amounts of single or multiple antibodies for pilot testing. Custom antibody labeling with biotin or fluorescent tags is available upon request. Larger amounts of labeled or endotoxin-low antibody can be prepared under special order at discounted pricing.

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