GMA-8018

Murine Anti- Factor VIII

Clone GMA-8018

Background

Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8018 (also known as 5G12 or 5G12.1B) recognizes the light chain of FVIII. It inhibits FVIII activation, and is suitable for ELISA applications.

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human, Mouse, Pig
Source: Murine
Specificity: Light Chain
Immunogen: B-domain deleted recombinant Human Factor VIII
Isotype: IgG2a

Application

ELISA: Binds immobilized human, porcine, and murine FVIII.
Immunoblotting: Not recommended.
Inhibition: Inhibitory in aPTT clotting assay.

Data:

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Antibody References:

  1. A. van der Flier et al. (2015). PLoS One. 10(4):e0124930.
  2. Q. Wang et al. (2016). Gene Ther. 23(7):597–605.
  3. J. Firrman et al. (2020). Molecular Therapy: Methods & Clinical Development. 17:328-336.
  4. Q. Wang et al. (2014). Human Gene Therapy Methods. 25:261-268.