GMA-8024

Clone GMA-8024

Background

Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca²⁺ . Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8024 (also known as 2-101) recognizes the A2 domain of FVIII and can be used in conjunction with GMA-8023 as a sandwich ELISA pair for detection of human FVIII. It does not bind murine, rhesus or cynomolgus FVIII.