GMA-166
Murine Anti- Factor IX
Clone GMA-166
Background
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Absent or defective FIX is the cause of the X-linked recessive bleeding disorder hemophilia B. GMA-166 binds to the activation peptide in FIX as detected by Western blot and ELISA, and it extends clotting time in a one-stage aPTT assay.
More Information:
Product Datasheet, pdfDescription
Species Reactivity: Human
Source: Murine
Specificity: Activation peptide
Immunogen: Human Factor IX peptide (CGGAETVFPDVDYVNSTEA ETILDNITQSTQSFNDFTR) conjugated to KLH.
Isotype: IgG1
Application
ELISA: Binds immobilized human FIX.
Immunoblotting: Western blot detects human FIX under reduced and non-reduced conditions.
Data:
