GMA-020

Murine Anti- Thrombin

Clone GMA-020

Background

Thrombin, the protease cleavage product of prothrombin by prothrombinase, is a two-chain protein (Mr 37,000) consisting of an amino-terminal A chain (Mr 6,000) disulfide-bonded to a carboxyl-terminal B chain (Mr 31,000). Thrombin has numerous physiological roles including cleavage of Aα and Bβ peptides of fibrinogen to form fibrin, activation of factor V, factor VIII, and protein C, and platelet activation via cleavage of PAR-1 and PAR-4. Antibody binds immobilized human thrombin, prothrombin, prethrombin 1 and prethrombin 2 in ELISA.

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human
Source: Murine
Specificity: a-thrombin B-chain (residues 321- 579 of prothrombin)
Immunogen: Human Thrombin
Isotype: IgG1

Application

ELISA: Binds immobilized human thrombin, prothrombin, prethrombin 1 and prethrombin 2.
Immunoblotting: Western blot detects thrombin, prothrombin, prethrombin 1 and prethrombin 2

Data:

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