GMA-072
Murine Anti- Factor XI
Clone GMA-072
Background
Factor XI is a key player in the intrinsic blood coagulation pathway. It circulates in complex with high molecular weight kininogen. When activated by factor XIIa, thrombin, or autoactivation, the activated form factor XIa contributes to both hemostasis and thrombosis by amplifying thrombin generation and fibrin formation leading to clot formation. Human factor XI has a molecular weight of 160 kDa and is comprised of a disulfide-linked dimer, with each monomer containing four apple domains that form a ring around the base of the catalytic domain. GMA-072 is suitable for ELISA and western blot applications.
More Information:
Product Datasheet, pdfDescription
Species Reactivity: Human
Source: Murine
Specificity: Factor XI/XIa
Isotype: IgG1
Application
ELISA: Binds immobilized factor XI.
Immunoblotting: Western blot detects factor XI and factor XIa under non-reduced conditions.
Data:
