Murine Anti- Factor IX
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Defect or deficiencies in FIX lead to the X-linked recessive bleeding disorder hemophilia B. GMA-102 (also known as GMA-002) binds to FIX and detects the heavy chain of FIXa in both ELISA and Western blot format, and bound GMA-102 captures FIX by bio-layer interferometry.
More Information:Product Datasheet, pdf
Species Reactivity: Human, Porcine
Specificity: Heavy chain of FIX/FIXa
Immunogen: Human Factor IX
ELISA: Binds immobilized Human and Porcine FIX and Human IXa.
Immunoblotting: Western blot detects Human FIX and heavy chain of Human FIXa under reduced conditions.
Inhibition: Prolongs plasma clot time in APTT clotting assay.
BLI: KD=6 nM (kdis=4.6 x 10-3 sec-1) by bio-layer interferometry
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