GMA-162

Murine Anti- Factor IX

Clone GMA-162

Background

Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Absent or defective FIX is the cause of the X-linked recessive bleeding disorder hemophilia B. GMA-162 (16E11) binds to Factor IXa but not FIX, as detected by Western blot and ELISA1. It can be used in a sandwich ELISA with GMA-164 to detect free Factor IXa and Factor IX in complex with antithrombin1.

More Information:

Product Datasheet, pdf

Description

Species Reactivity: Human
Source: Murine
Specificity: Factor IXa heavy chain
Immunogen: Human Factor IXa peptide (VVGGEDAKPGQFPWQC) conjugated to KLH.
Isotype: IgG1

Application

ELISA: Binds immobilized human FIXa
Immunoblotting: Western blot detects heavy chain of human FIXa under reduced conditions.

Data:

Validation data of western blot and ELISA for GMA-162

Purchase GMA-162

  • 0.5 mg/$660.00
  • 0.1 mg/$265.00
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