GMA-168
Murine Anti- Factor IX/IXa
Clone GMA-168
Background
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Absent or defective FIX is the cause of the X-linked recessive bleeding disorder hemophilia B. GMA-168 binds to the N-terminus of the light chain of FIX/FIXa, as detected by Western blot and ELISA, and extends clotting time in aPTT assay.
More Information:
Product Datasheet, pdfDescription
Species Reactivity: Human
Source: Murine
Specificity: N-terminal peptide
Immunogen: Human FIX peptide (YNSGKL(gla)(gla)FVQGNLGGC) conjugated to KLH
Isotype: IgG1
Application
ELISA: Binds immobilized human FIX and FIXa.
Immunoblotting: Western blot detects light chain of human FIX and FIXa under reduced and non-reduced conditions.
Data:
