Murine Anti- Factor VIII
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor (vWF). Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8014 (also known as 3G6 or 3G6.1B)1 recognizes the C2 domain of FVIII. The antibody strongly inhibits FVIII activation and is unaffected by the presence of vWF or phospholipid membranes.1 GMA-8014 detects FVIII C2 domain by surface plasmon resonance,2,3 and is suitable for ELISA and bio-layer interferometry pairing experiments.
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