Murine Anti- Factor VIII
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+ . Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA- 8021 (also known as 2-76 or 76-1B) recognizes the A2 domain of FVIII, is strongly inhibitory 1 , and suitable for ELISA and bio-layer interferometry applications.
More Information:Product Datasheet, pdf
- R.C. Markovitz et al. (2013). Blood. 121(14):2785-2795.
- J. Gewirtz et al. (2008). J Thromb Haemost. 6(7):1160-1166.
- R.B. Lyde et al. Blood Advances. (2019). 3(9):1368-1378.
- G. D. Minno et al. (2014). Haemophilia. 20 (Suppl. 6):27–43.
- G.E. Gilbert et al. (2012). Blood. 120(9):1923–1932.
- V.A. Novakovic et al. (2011). Biochem J. 435(1):187–196.
Not sure what you need?
Our expert team will guide you every step of the way.