GMA-8028
Murine Anti- Factor VIII
Clone GMA-8028
Background
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8028 (also known as 2-54 or 54-1C) recognizes the A2 domain of FVIII, is strongly inhibitory1, and is suitable for ELISA and Western blot applications.
More Information:
Product Datasheet, pdfDescription
Species Reactivity: Human
Source: Murine
Specificity: A2 domain
Immunogen: B-domain deleted recombinant Human Factor VIII
Isotype: IgG1
Application
ELISA: Binds immobilized human FVIII.
Immunoblotting: Western blot detects A2 domain of human FVIII.
Inhibition: Strongly inhibitory in aPTT clotting assay.1
Data:
